Journal
NATURE REVIEWS CANCER
Volume 8, Issue 9, Pages 714-724Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2401
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Funding
- NIH [CA10617, CA104213, CA099996, CA116777]
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The retinoblastoma tumour suppressor (RB) is a crucial regulator of cell-cycle progression that is invoked in response to a myriad of anti-mitogenic signals. It has been hypothesized that perturbations of the RB pathway confer a synonymous proliferative advantage to tumour cells; however, recent findings demonstrate context-specific outcomes associated with such lesions. Particularly, loss of RB function is associated with differential response to wide-ranging therapeutic agents. Thus, the status of this tumour suppressor may be particularly informative in directing treatment regimens.
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