Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume 165, Issue 3, Pages 201-216Publisher
WILEY
DOI: 10.1002/ajmg.b.32225
Keywords
transposable elements; retrotransposition; psychiatric disorders; long interspersed element 1; regulatory elements
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Funding
- NIMH NIH HHS [R01 MH085548] Funding Source: Medline
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Transposable Elements (TEs) or transposons are low-complexity elements (e.g., LINEs, SINEs, SVAs, and HERVs) that make up to two-thirds of the human genome. There is mounting evidence that TEs play an essential role in genomic architecture and regulation related to both normal function and disease states. Recently, the identification of active TEs in several different human brain regions suggests that TEs play a role in normal brain development and adult physiology and quite possibly in psychiatric disorders. TEs have been implicated in hemophilia, neurofibromatosis, and cancer. With the advent of next-generation whole-genome sequencing approaches, our understanding of the relationship between TEs and psychiatric disorders will greatly improve. We will review the biology of TEs and early evidence for TE involvement in psychiatric disorders. (c) 2014 Wiley Periodicals, Inc.
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