Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume 159B, Issue 4, Pages 437-444Publisher
WILEY
DOI: 10.1002/ajmg.b.32047
Keywords
GWAS; alcohol and nicotine co-dependence; risk region
Categories
Funding
- National Alliance for Research on Schizophrenia and Depression (NARSAD) [17616]
- National Institute on Drug Abuse (NIDA) [K01 DA029643, K24 DA017899, R01 DA016750, K02 DA026990, R01 DA013423]
- National Institute on Alcohol Abuse and Alcoholism (NIAAA) [R01 AA016015, R21 AA020319, K24 AA013736, P50 AA012870, U10 AA008401]
- Genes, Environment and Health Initiative (GEI) [U01HG004422, U01HG004438]
- GENEVA Coordinating Center [U01 HG004446]
- National Cancer Institute [P01 CA089392]
- NIH [HHSN268200782096C]
- Department of Veterans Affairs, VA Alcohol Research Center
- Department of Veterans Affairs, VA National Center for PTSD
- Department of Veterans Affairs, Depression REAP
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The present study searched for replicable risk genomic regions for alcohol and nicotine co-dependence using a genome-wide association strategy. The data contained a total of 3,143 subjects including 818 European-American (EA) cases with alcohol and nicotine co-dependence, 1,396 EA controls, 449 African-American (AA) cases, and 480 AA controls. We performed separate genome-wide association analyses in EAs and AAs and a meta-analysis to derive combined P-values, and calculated the genome-wide false discovery rate (FDR) for each SNP. Regions with P?
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