Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume 159B, Issue 7, Pages 803-811Publisher
WILEY
DOI: 10.1002/ajmg.b.32087
Keywords
Drive for Thinness; Body Dissatisfaction; Childhood Obsessive Compulsive Personality Disorder; Weight Fluctuation; Breakfast Skipping
Categories
Funding
- Wellcome Trust
- European Community [HEALTH-F2-2008-201865-GEFOS, HEALTH-F42007- 201413, QLG2-CT-2002-01254]
- Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre
- Biotechnology and Biological Sciences Research Council (BBSRC) [G20234]
- National Eye Institute via an NIH/CIDR genotyping project
- NEI/NIH
- European Union (European Social Fund-ESF)
- National Strategic Reference Framework (NSRF)
- Greek national funds through the Operational Program Education and Lifelong Learning'' of the National Strategic Reference Framework (NSRF)-Research Funding Program: Heracleitus II
- Unity Through Knowledge Fund CONNECTIVITY PROGRAM (Gaining Experience'') [2A]
- National Foundation for Science, Higher Education and Technological Development of the Republic of Croatia (BRAIN GAIN-Postdoc fellowship)
- Wellcome Trust [098051]
- Wellcome Trust WTCCC3 project [WT090355/A/09/Z, WT090355/B/09/Z]
- European Commission [QLK-1999-916]
- Wellcome Trust Sir Henry Wellcome Fellowship [WT088984]
- Marie Curie Program (INTACT network) [MRTN-CT-2006-035988]
- Marie Curie program [FP7-PEOPLE-2009-IEF]
- National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health award
- Institute of Psychiatry, King's College London
- Academy of Finland [28327, 100499, 205585, 141054]
- ENGAGE-European Network for Genetic and Genomic Epidemiology [201413]
- Academy of Finland Center of Excellence in Complex Disease Genetics [213506, 129680]
- National Institute of Alcohol Abuse and Alcoholism [AA-12502, AA-00145, AA-09203, AA15416, K02AA018755]
Ask authors/readers for more resources
Eating disorders (EDs) are common, complex psychiatric disorders thought to be caused by both genetic and environmental factors. They share many symptoms, behaviors, and personality traits, which may have overlapping heritability. The aim of the present study is to perform a genome-wide association scan (GWAS) of six ED phenotypes comprising three symptom traits from the Eating Disorders Inventory 2 [Drive for Thinness (DT), Body Dissatisfaction (BD), and Bulimia], Weight Fluctuation symptom, Breakfast Skipping behavior and Childhood Obsessive-Compulsive Personality Disorder trait (CHIRP). Investigated traits were derived from standardized self-report questionnaires completed by the TwinsUK population-based cohort. We tested 283,744 directly typed SNPs across six phenotypes of interest in the TwinsUK discovery dataset and followed-up signals from various strata using a two-stage replication strategy in two independent cohorts of European ancestry. We meta-analyzed a total of 2,698 individuals for DT, 2,680 for BD, 2,789 (821 cases/1,968 controls) for Bulimia, 1,360 (633 cases/727 controls) for Childhood Obsessive-Compulsive Personality Disorder trait, 2,773 (761 cases/2,012 controls) for Breakfast Skipping, and 2,967 (798 cases/2,169 controls) for Weight Fluctuation symptom. In this GWAS analysis of six ED-related phenotypes, we detected association of eight genetic variants with P?
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available