Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume 156B, Issue 8, Pages 969-974Publisher
WILEY-BLACKWELL
DOI: 10.1002/ajmg.b.31244
Keywords
bipolar disorder; schizophrenia; ANK3; genetic association
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Funding
- University of Oslo
- Research Council of Norway [167153/V50, 163070/V50]
- SouthEast Norway Health Authority [2004123]
- Danish National Psychiatric Research Foundation
- Lundbeck Foundation
- Ivan Nielsen Foundation
- Stanley Medical Research Institute
- Wallenberg Foundation
- HUBIN Project
- Swedish Medical Research Council [2006-2992, 2006-986, 2008-2167]
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Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case-control sample (N = 854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case-control sample (N = 1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N = 435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N = 1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P = 0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P = 0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case-control sample (N = 1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved. (C) 2011 Wiley Periodicals, Inc.
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