Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume 153B, Issue 4, Pages 937-947Publisher
WILEY
DOI: 10.1002/ajmg.b.31063
Keywords
NRXN1 (neurexin-1); developmental disorders; array CGH; NRXN1 exonic deletions; CNV
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Funding
- Nancy Lurie Marks Family Foundation
- Simons Foundation
- Autism Speaks
- NIH [5K23MH080954-02, 1R01MH083565]
- Children's Tumor Foundation
- Harvard Medical School
- Burroughs Wellcome Fund
- Fudan University
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Research has implicated mutations in the gene for neurexin-1 (NRXN1) in a variety of conditions including autism, schizophrenia, and nicotine dependence. To our knowledge, there have been no published reports describing the breadth of the phenotype associated with mutations in NRXN1. We present a medical record review of subjects with deletions involving exonic sequences of NRXN1. We ascertained cases from 3,540 individuals referred clinically for comparative genomic hybridization testing from March 2007 to January 2009. Twelve subjects were identified with exonic deletions. The phenotype of individuals with NRXN1 deletion is variable and includes autism spectrum disorders, mental retardation, language delays, and hypotonia. There was a statistically significant increase in NRXN1 deletion in our clinical sample compared to control populations described in the literature (P=8.9 x 10(-7)). Three additional subjects with NRXN1 deletions and autism were identified through the Homozygosity Mapping Collaborative for Autism, and this deletion segregated with the phenotype. Our study indicates that deletions of NRXN1 predispose to a wide spectrum of developmental disorders. (C) 2010 Wiley-Liss, Inc.
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