Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume 153B, Issue 7, Pages 1347-1349Publisher
WILEY-BLACKWELL
DOI: 10.1002/ajmg.b.31108
Keywords
bipolar disorder; schizoaffective disorder; GABA(A) receptor; genetics
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Funding
- Wellcome Trust
- Medical Research Council
- MRC [G0801418] Funding Source: UKRI
- Medical Research Council [G0801418B, G0801418] Funding Source: researchfish
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We have previously reported evidence that variation at GABA(A) receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P 0.052). (c) 2010 Wiley-Liss, Inc.
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