Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume 153B, Issue 7, Pages 1292-1297Publisher
WILEY
DOI: 10.1002/ajmg.b.31100
Keywords
bipolar disorder; genetics; association
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Funding
- National Institute for Health Research (NIHR)
- NIH [5R01MH059534-08, U24 MH068457]
- National Institute of Mental Health
- MRC [G0501329] Funding Source: UKRI
- Medical Research Council [G0501329] Funding Source: researchfish
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We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2 x 10(-5)). Both P-values are in the top 5% of the distribution derived from null simulations (P 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP. (c) 2010 Wiley-Liss, Inc.
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