Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume 150B, Issue 1, Pages 12-23Publisher
WILEY-LISS
DOI: 10.1002/ajmg.b.30891
Keywords
CREB; serotonin; animal model; brain; behavior; major depression; antidepressant
Categories
Funding
- National Research Service Award [T32 MH18273]
- Veterans Administration (ME)
- Burroughs Welcome Fund Career Award in the Biomedical Sciences (ME)
- National Institute of Mental Health [MH47346]
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The cAMP-response element binding protein (CREB)-mediated cell signaling pathway is conserved through evolution and participates in a broad range of complex behaviors of divergent species including man. This study describes the integration of genetic, pharmacologic, and anatomic methods to elucidate a serotonergic signaling pathway by which the CREB homolog CRH-1 controls foraging rate (FR) in the model organism Caenorhabditis elegans, along with the complete neuronal circuit through which this pathway operates. In the anterior afferent arm of the circuit, CRH-1 controls FR by regulating the expression of tph-1, the sole structural gene for tryptopban hydroxylase, in serotonergic sensory (ADF) neurons whose post-synaptic effects are mediated through 5HT(2)-like SERA receptors. The posterior afferent limb of the circuit includes an interneuron (RIH) that does not express tph-1 and whose serotonergic phenotype is dependent on the contribution of this neurotransmitter from another source, probably the ADF neurons. The postsynaptic effects of the RIH interneuron are mediated through 5HT(1)-like SER-4 receptors. This model has potential utility for the study of clinical disorders and experimental therapeutics. Furthermore, the discovery of serotonergic neurons that depend on other sources for their neurotransmitter phenotype could provide a mechanism for rapidly altering the number and distribution of serotonergic pathways in developing and adult nervous systems, providing a dimension of functional complexity that has been previously unrecognized.. (C) 2008 Wiley-Liss, Inc.
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