4.2 Article

WNT10A and Isolated Hypodontia

Journal

AMERICAN JOURNAL OF MEDICAL GENETICS PART A
Volume 155A, Issue 5, Pages 1119-1122

Publisher

WILEY-BLACKWELL
DOI: 10.1002/ajmg.a.33840

Keywords

ectodermal dysplasia; missing teeth; hypodontia; odonto-onycho-dermal dysplasia; tricho-odonto-onycho-dermal dysplasia; nail dysplasia

Funding

  1. Thailand Research Fund (TRF)
  2. European Community [LSHBCT -2005-019067]
  3. Faculty of Dentistry, Chiang Mai University

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WNT10A has been associated with various syndromes with ectodermal dysplasia from severe autosomal recessive SchO? pf-Schulz-Passarge syndrome to odonto-onycho-dermal dysplasia and autosomal dominant hypodontia. We report WNT10A mutations in an American family of which four members are affected with isolated hypodontia or microdontia. Here we demonstrate that in addition to MSX1, PAX9, AXIN2, and EDA, mutations in WNT10A can cause isolated hypodontia. (C) 2011 Wiley-Liss, Inc.

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