Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 18, Pages 9965-9971Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b02276
Keywords
surface-enhanced Raman scattering; circulating tumor cells; direct detection; blood; excellent specificity; high sensitivity
Funding
- National Natural Science Foundation of China [51203175, 51411140243, 61171033]
- Zhejiang Provincial Natural Science Foundation of China [LQ13E030004]
- Chinese Academy of Sciences [2010-735]
- National Research Foundation of Korea [NRF-2014K2A2A2000720]
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The detection of circulating tumor cells (CTCs) in the blood of cancer patients is crucial for early can(er diagnosis, cancer prognosis, evaluation of the treatment effect of chemotherapy drugs, and choice of cancer treatment options. In this study, we propose new surface-enhanced Raman scattering (SERS) nanoparticles for the direct detection of CTCs in the blood. Under the optimized experimental conditions, our SERS nanoparticles exhibit satisfying performances for the direct detection of cancer cells in the rabbit blood. A good linear relationship is obtained between the SERS intensity and the concentration of cancer cells in the range of 5-500 cells/mL (R-2 = 0.9935), which demonstrates that the SERS nanoparticles can be used for the quantitative analysis of cancer cells in the blood and the limit of detection is 5 cells/mL, which is lowest compared with the reported values. The SERS nanoparticles also have an excellent specificity for the detection of cancer cells in the rabbit blood. The above results reinforce that our SERS nanoparticles can be used for the direct detection of CTCs in the blood with excellent specificity and high sensitivity.
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