4.6 Article

Utilization and Costs of Medications Associated With CKD Mineral and Bone Disorder in Dialysis Patients Enrolled in Medicare Part D

Journal

AMERICAN JOURNAL OF KIDNEY DISEASES
Volume 64, Issue 5, Pages 770-780

Publisher

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ajkd.2014.04.014

Keywords

Chronic kidney disease (CKD); Medicare Part D; medication costs; dialysis; mineral and bone disorder; phosphate binders; calcimimetics; vitamin D analogues

Funding

  1. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health [HHSN267200715002C]

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Background: Information is limited regarding utilization patterns and costs for chronic kidney disease-mineral and bone disorder (CKD-MBD) medications in Medicare Part D-enrolled dialysis patients. Study Design: Retrospective cohort study. Setting & Participants: Annual cohorts of dialysis patients, 2007-2010. Predictors: Cohort year, low-income subsidy status, and dialysis provider. Outcomes: Utilization and costs of prescription phosphate binders, oral and intravenous vitamin D analogues, and cinacalcet. Measurements: Using logistic regression, we calculated adjusted odds of medication use for low-income subsidy versus non-low-income subsidy patients and for patients from various dialysis organizations, and we report per-member-per-month and average out-of-pocket costs. Results: Phosphate binders (similar to 83%) and intravenous vitamin D (77.5%-79.3%) were the most commonly used CKD-MBD medications in 2007 through 2010. The adjusted odds of prescription phosphate-binder, intravenous vitamin D, and cinacalcet use were significantly higher for low-income subsidy than for non-low-income subsidy patients. Total Part D versus CKD-MBD Part D medication costs increased 22% versus 36% from 2007 to 2010. For Part D-enrolled dialysis patients, CKD-MBD medications represented similar to 50% of overall net Part D costs in 2010. Limitations: Inability to describe utilization and costs of calcium carbonate, an over-the-counter agent not covered under Medicare Part D; inability to reliably identify prescriptions filled through a non-Part D reimbursement or payment mechanism; findings may not apply to dialysis patients without Medicare Part D benefits or with Medicare Advantage plans, or to pediatric dialysis patients; could identify only prescription drugs dispensed in the outpatient setting; inability to adjust for MBD laboratory values. Conclusions: Part D net costs for CKD-MBD medications increased at a faster rate than costs for all Part D medications in dialysis patients despite relatively stable use within medication classes. In a bundled environment, there may be incentives to shift to generic phosphate binders and reduce cinacalcet use. (C) 2014 by the National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

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