Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 75, Issue 2, Pages 134-145Publisher
WILEY
DOI: 10.1111/aji.12458
Keywords
Biomarker; female reproductive tract; gamma delta T cells; HIV
Categories
Funding
- National Institute of Allergy and Infectious Diseases
- Women's Interagency HIV Infection Study (WIHS) [U01 AI103397]
- National Institute of Allergy and Infectious Diseases, National Institutes of Health [P30AI073961]
- National Center for Advancing Translational Sciences
- National Institute on Minority Health and Health Disparities, National Institute of Health [UL1TR000460, 1KL2TR000461]
- National Institute of Child Health and Human Development, National Institute of Health [K23HD074489]
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Problem Human gamma delta (GD) T cells play a well-documented role in epithelial barrier surveillance and protection. Two subsets of GD T cells, defined by the use of either the Vdelta2 (GD2) or Vdelta1 (GD1) TCR, predominate. We hypothesized that endocervical GD T cells play important role in lower genital tract anti-HIV immune responses. Method of study HIV-infected (n = 18) and HIV-uninfected (n = 19) pre-menopausal women participating in the WIHS cohort were recruited. Frequency and phenotype of GD T cells were determined in endocervical cytobrush samples and peripheral blood by multicolor flow cytometry. Results We found depletion of GD2 cells in the blood of HIV-infected women as well as significant decrease in the frequency of endocervical GD1 cells compared to uninfected women. Conclusion We report for the first time, the GD1 cells are a predominant endocervical T-cell subset that is significantly decreased in HIV-infected women.
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