Journal
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Volume 38, Issue 9, Pages 1642-1653Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-008-0546-x
Keywords
Prader-Willi syndrome; fMRI; hypothalamus; food-related; genetic
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Funding
- NICHD NIH HHS [L30 HD048198, L30 HD048198-01, P01 HD03008] Funding Source: Medline
- NIMH NIH HHS [T32 MH 18268] Funding Source: Medline
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Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by hyperphagia and food preoccupations. Although dysfunction of the hypothalamus likely has a critical role in hyperphagia, it is only one of several regions involved in the regulation of eating. The purpose of this research was to examine food-related neural circuitry using functional magnetic resonance imaging in individuals with PWS and matched controls. Individuals with PWS showed increased activation in neural circuitry known to mediate hunger and motivation (hypothalamus, OFC) in response to high- versus low-calorie foods and in comparison to controls. This suggests neural circuitry for PWS is abnormally activated during hunger, particularly for high-calorie foods, and may mediate abnormally strong hunger states, therefore playing a significant role in PWS-induced hyperphagia.
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