Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 75, Issue 2, Pages 81-85Publisher
WILEY
DOI: 10.1111/aji.12465
Keywords
FcRn; immunoglobulin (IgG); intestinal transfer; passive immunization; placental transfer
Categories
Funding
- Ph.D. Programs Foundation of Ministry of Education of China [20130204110023]
- extension Project of the Research Fellowship for International Young Scientists, Ministry of Education [31450110455]
- State Administration of Foreign Experts Affairs 'Overseas Teacher' project [MS2011XBNL057]
Ask authors/readers for more resources
Problem IgG is transformed from maternal serum into the offspring as passive immunization by FcRn expressed in placenta and/ or infant intestine. This study aimed to investigate the quantitative correlation between IgG and FcRn during gestation and lactating periods in rat. Method of Study ELISA was performed to determine the variation of maternal and offspring IgG. Western blot and RT-qPCR were carried out to characterize FcRn expression in placenta and infant intestine. Results Maternal serum IgG appeared higher in first 2 weeks of lactation. The embryo IgG was in accordance with the FcRn expression in placenta. During the post-natal, the serum IgG concentration in feta was obviously lower than maternal IgG on day 0 before uptaking colostrums and rapidly increased on day 1. Conclusion These findings would provide clues for the endogenous transportation and exogenous administration of IgG for a better IgG intervention in offspring.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available