Spectrophotometric Determination of Sulfanilamides by a Condensation Reaction with p-Dimethylaminocinnamaldehyde

p-Dimethylaminocinnamaldehyde has been proposed as a reagent for the spectrophotometric determination of sulfanilamides. This reagent was shown to undergo in acetonitrile a condensation reaction with sulfanilamide, Sulfamethoxypyridazine, Sulfachloropyridazine, Sulfamethoxazole, and Sulfamethazine to form colored products. Optimal reaction conditions were found. A procedure for the spectrophotometric determination of sulfanilamide compounds with detection limit n x 10(-2) mu g/mL was developed. Determination of Sulfamethoxazole and Sulfamethazine in pharmaceuticals was carried out.