Journal
AMERICAN JOURNAL OF HYPERTENSION
Volume 22, Issue 8, Pages 896-903Publisher
OXFORD UNIV PRESS
DOI: 10.1038/ajh.2009.83
Keywords
-
Categories
Funding
- Direccion General de Investigacion
- Ministerio de Educacion y Ciencia [SAF2006-6254-FEDER]
- Conselleria de Presidencia
- Relacions Institucionais a Administracion Poblica
- Secretaria Xeral de Investigacion a Desenvolvemento
- Xunta de Galicia [PGIDIT03-PXIB-32201PR, INCITE07-PXI-322003ES, INCITE08-E1R-3220063ES]
- Conselleria de Educacion a Ordenacion Universitaria
- Direccidin Xeral de Promocion Cientifica eTecnoloxica do Sistema Universitario de Galicia
- Conselleria de Innovacion a Industria, Direccion Xeral de Investigacion
- Desenvolvemento a Innovacion
Ask authors/readers for more resources
BACKGROUND Aspirin has been found to prevent angiotensin II-induced hypertension and to induce nitric oxide (NO) release from vascular endothelium. Low-dose aspirin has also been shown to reduce blood pressure (BP) when administered at bedtime, as opposed to upon awakening, in untreated hypertensive patients and high-risk pregnant women. Accordingly, we investigated the effects on ambulatory BP of aspirin administered at different times of the day in prehypertension. METHODS We studied 244 subjects with prehypertension, 43.0 +/- 13.0 years of age, randomly divided in three groups: nonpharmacological hygienic-dietary recommendations; the same recommendations and aspirin (100 mg/day) on awakening; or the same recommendations and aspirin at bedtime. BP was measured for 48 consecutive hours before and after 3 months of intervention. RESULTS Ambulatory BP was unchanged in subjects randomized to either nonpharmacological intervention or aspirin on awakening. A significant ambulatory BP reduction was, however, observed in the subjects who received aspirin at bedtime (decrease of 6/3 mm Hg in the 24-h mean of systolic (SBP)/diastolic BP (DBP), respectively; P < 0.001), without changes in heart rate (HR) from baseline. BP was homogenously controlled along the 24 h after bedtime aspirin administration (6/4 mm Hg reduction in activity mean of SBP/DBP; 6/3 mm Hg reduction in sleep-time mean, respectively). CONCLUSIONS This prospective trial documents a significant effect on BP of low-dose aspirin only when ingested at bedtime by prehypertensive subjects. The timed administration of low-dose aspirin could thus provide a valuable and cost-effective approach for BP control in subjects at elevated risk of developing hypertension. Am J Hypertens 2009; 22:896-903 (C) 2009 American Journal of Hypertension, Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available