Journal
AMERICAN JOURNAL OF HUMAN GENETICS
Volume 94, Issue 1, Pages 5-10Publisher
CELL PRESS
DOI: 10.1016/j.ajhg.2013.12.008
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Funding
- NCATS NIH HHS [UL1 TR001079] Funding Source: Medline
- NIDDK NIH HHS [R01 DK044003] Funding Source: Medline
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Clinical genetic testing has undergone a dramatic transformation in the past two decades. Diagnostic laboratories that previously tested for well-established disease-causing DNA variants in a handful of genes have evolved into sequencing factories identifying thousands of variants of known and unknown medical consequence. Sorting out what does and does not cause disease in our genomes is the next great challenge in making genetics a central feature of healthcare. I propose that closing the gap in our ability to interpret variation responsible for Mendelian disorders provides a grand and unprecedented opportunity for geneticists. Human geneticists are well placed to coordinate a systematic evaluation of variants in collaboration with basic scientists and clinicians. Sharing of knowledge, data, methods, and tools will aid both researchers and healthcare workers in achieving their common goal of defining the pathogenic potential of variants. Generation of variant annotations will inform genetic testing and will deepen our understanding of gene and protein function, thereby aiding the search for molecular targeted therapies.
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