Journal
INTERNATIONAL JOURNAL OF EATING DISORDERS
Volume 48, Issue 7, Pages 814-825Publisher
WILEY
DOI: 10.1002/eat.22400
Keywords
genome-wide association; anorexia nervosa; genetic overlap between disorders; genetic architecture; heritability; candidate gene
Funding
- Marie Curie Research Training Network INTACT [MRTN-CT-2006-035988]
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BackgroundEven though the evidence supporting the presence of a heritable component in the aetiology of anorexia nervosa (AN) is strong, the underlying genetic mechanisms remain poorly understood. The recent publication of a genome-wide association study (GWAS) of AN (Boraska, Mol Psychiatry, 2014) was an important step in genetic research in AN. ObjectiveTo briefly sum up strengths and weaknesses of candidate-gene and genome-wide approaches, to discuss the genome-wide association studies of AN and to make predictions about the genetic architecture of AN by comparing it to that of schizophrenia (since the diseases share some similarities and genetic research in schizophrenia is more advanced). MethodDescriptive literature review. ResultsDespite remarkable efforts, the gene-association studies in AN did not advance our knowledge as much as had been hoped, although some results still await replication. DiscussionContinuous effort of participants, clinicians and researchers remains necessary to ensure that genetic research in AN follows a similarly successful path as in schizophrenia. Identification of genetic susceptibility loci provides a basis for follow-up studies. (c) 2015 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:814-825)
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