Journal
AMERICAN JOURNAL OF HUMAN GENETICS
Volume 85, Issue 5, Pages 750-755Publisher
CELL PRESS
DOI: 10.1016/j.ajhg.2009.10.009
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Funding
- Australian National Health and Medical Research Council [241944, 339462, 389927, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 552485, 552498]
- Australian Research Council [A7960034, A79906588, A79801419, DP0770096, DP0212016, DP0343921]
- FP-S GenomEUtwin Project [QLG2-CT-2002-01254]
- U.S. National Institutes of Health (NIH) [AA07535, AA10248, AA13320, AA13321, AA13326, AA14041, MH66206]
- Netherlands Scientific Organization [NWO 480-05-003]
- National Health and Medical Research Council (NHMRC)
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Hair morphology is highly differentiated between populations and among people of European ancestry. Whereas hair morphology in East Asian populations has been studied extensively, relatively little is known about the genetics of this trait in Europeans. We performed a genome-wide association scan for hair morphology (straight, wavy curly) in three Australian samples of European descent. All three samples showed evidence of association implicating the Trichohyalin gene (TCHH), which is expressed in the developing inner root sheath of the hair follicle, and explaining similar to 6% of variance (p 1.5 x 10(-31)). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations.
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