Journal
AMERICAN JOURNAL OF HUMAN GENETICS
Volume 84, Issue 3, Pages 367-379Publisher
CELL PRESS
DOI: 10.1016/j.ajhg.2009.02.001
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Funding
- NIMH NIH HHS [MH074027, R01 MH077139, MH081802, R01 MH081802, MH077139, R01 MH074027] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples(n - 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.
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