Journal
NATURE REVIEWS IMMUNOLOGY
Volume 8, Issue 11, Pages 861-873Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2434
Keywords
-
Categories
Funding
- NCI NIH HHS [P01 CA069381-130001, P01 CA069381] Funding Source: Medline
- NIAID NIH HHS [R01 AI067890-01A2, R01 AI048073-08, R37 AI033068-16, R01 AI057840, R37 AI033068, R01 AI057840-04, R01 AI048073, R01 AI067890-02, R01 AI067890] Funding Source: Medline
Ask authors/readers for more resources
Herpesviruses have evolved numerous strategies to subvert host immune responses so they can coexist with their host species. These viruses 'co-opt' host genes for entry into host cells and then express immunomodulatory genes, including mimics of members of the tumour-necrosis factor (TNF) superfamily, that initiate and alter host-cell signalling pathways. TNF superfamily members have crucial roles in controlling herpesvirus infection by mediating the direct killing of infected cells and by enhancing immune responses. Despite these strong immune responses, herpesviruses persist in a latent form, which suggests a dynamic relationship between the host immune system and the virus that results in a balance between host survival and viral control.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available