Journal
AMERICAN JOURNAL OF HEMATOLOGY
Volume 85, Issue 2, Pages 101-105Publisher
WILEY
DOI: 10.1002/ajh.21585
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Funding
- National Heart, Blood and Lung Institute (NHLBI)
- University of Minnesota [N01-HC-05185]
- Howard University [N01-HC-05186, UH1-HL03679-05]
- Kaiser Permanente Center for Health Research [N01-HC-05189]
- University of California, Irvine [N01-HC-05190, R01 HL083328-01A1]
- London Health Sciences Centre [N01-HC-05191]
- Wake Forest University [N01-HC-05192]
- National Center for Research Resources, National Institutes of Health
- University of Alabama at Birmingham General Clinical Research Center (GCRC)
- Southern Iron Disorders Center [M01-RR00032]
- Howard University General Clinical Research Center (GCRC) [M01-RR10284, M01-RR00827-29]
- National Heart, Lung, and Blood Institute
- Office of Research on Minority Health
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Heritability is the proportion of observed variation in a trait among individuals in a population that is attributable to hereditary factors. The Hemochromatosis and Iron Overload Screening family study estimated heritability of serum iron measures. Probands were HFE C282Y homozygotes or non-C282Y homozygotes with elevated transferrin saturation (TS > 50%, men; TS > 45%, women) and serum ferritin concentration (SF > 300 mu g/L, men; SF > 200 mu g/L, women). Heritability (h(2)) was estimated by variance component analysis of TS, natural logarithm (ln) of SF, and unsaturated iron-binding capacity (UIBC). Participants (N = 942) were 77% Caucasians, 10% Asians, 8% Hispanics, and 5% other race/ethnicities. Average age (SD) was 49 (16) years; 57% were female. For HFE C282Y homozygote probands and their family members, excluding variation due to HFE C282Y and H63D genotype and measured demographic and environmental factors, the residual h(2) (SE) was 0.21 (0.07) for TS, 0.37 (0.08) for In SF, and 0.34 (0.08) for UIBC (all P < 0.0004 for comparisons with zero). For the non-C282Y homozygote proband group, residual h(2) was significant with a value of 0.64 (0.26) for In SF (P = 0.0096). In conclusion, serum iron measures have significant heritability components, after excluding known genetic and nongenetic sources of variation. Am. J. Hematol. 85:101-105, 2010. (C) 2009 Wiley-Liss, Inc.
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