Journal
AMERICAN JOURNAL OF HEMATOLOGY
Volume 83, Issue 7, Pages 596-598Publisher
WILEY-LISS
DOI: 10.1002/ajh.21177
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Peripheral T-cell lymphoma (PTCL) is an aggressive form of non-Hodgkin's lymphoma (N - HL), associated with poor prognosis and without standard approach to treatment. Denileukin diftitox (Onta (R)) is a synthetic fusion protein combining the receptor-binding domain of interleukin-2 to the enzymatically active portion of diphtheria toxin. While approved for the treatment of cutaneous T-cell lymphoma, it has demonstrated activity in non-Hodgkin's lymphomas of both T-cell and B-cell origin. This report documents the first case of de novo maintenance therapy with denileukin diftitox sustaining an ongoing complete response at the molecular level for 2 years in a patient with PTCL.
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