Journal
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
Volume 22, Issue 10, Pages 1039-1046Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jagp.2013.02.005
Keywords
Late-life depression; antidepressant; hippocampus; amygdala; neuropsychological factors; cognitive deficit; age at onset; vascular risk factors; white matter hyperintensities; treatment outcome
Categories
Funding
- National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [P50AG05681, P01AG03991, RR00036, 1 UL1 RR024992-01, 1 TL1 RR024995-01, 1 KL2 RR 024994-01]
- NIH Roadmap for Medical Research
- Collaborative R01 for Clinical Studies of Mental Disorders [MH60697, MH62158]
- National Institute of Mental Health [K24 65421]
- Pfizer, Inc.
Ask authors/readers for more resources
Objective: To compare differences in gray matter volumes, white matter and subcortical gray matter hyperintensities, neuropsychological factors, and treatment outcome between early-and late-onset late-life depressed (LLD) subjects. Methods: We conducted a prospective, nonrandomized, controlled trial at the outpatient clinics at Washington University and Duke University on 126 subjects, aged 60 years or older, who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for major depression, scored 20 or more on the Montgomery-Asberg Depression Rating Scale (MADRS), and received neuropsychological testing and magnetic resonance imaging. Subjects were excluded for cognitive impairment or severe medical disorders. After 12 weeks of sertraline treatment, subjects' MADRS scores over time and neuropsychological factors were studied. Results: Left anterior cingulate thickness was significantly smaller in the late-onset depressed group than in the early-onset LLD subjects. The late-onset group also had more hyperintensities than the early-onset LLD subjects. No differences were found in neuropsychological factor scores or treatment outcome between early-onset and late-onset LLD subjects. Conclusion: Age at onset of depressive symptoms in LLD subjects are associated with differences in cortical thickness and white matter and subcortical gray matter hyperintensities, but age at onset did not affect neuropsychological factors or treatment outcome.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available