Journal
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
Volume 21, Issue 2, Pages 184-195Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jagp.2012.10.019
Keywords
Depression; gray matter; late life; magnetic resonance imaging; meta-analysis; MRI; systematic review
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Funding
- Gordon Edward Small's Charitable Trust, Edinburgh [SC008962]
- Medical Research Council [G1001354] Funding Source: researchfish
- MRC [G1001354] Funding Source: UKRI
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Gray matter abnormalities within frontal subcortical and limbic networks are hypothesized to play a key role in the pathophysiology of late-life depression. In this work, gray matter abnormalities in late-life depression are examined in a systematic review and meta-analysis of magnetic resonance imaging studies. In the systematic review, 27 articles were identified that compared participants with late-life depression with comparison group participants, and 17 studies were suitable for inclusion in meta-analyses of volumes of the whole brain, orbitofrontal cortex, caudate, hippocampus, putamen, and thalamus. Volume reductions were detected in 7 of 15 comparisons of the hippocampus and a meta-analysis revealed a significant, but small, effect size. Although examined by fewer studies, meta-analyses also revealed significant volume reductions in the orbitofrontal cortex, putamen, and thalamus. A more systematic and comprehensive analysis of the global distribution of gray matter abnormalities, and an examination of subcortical abnormalities were identified as key areas for future research. (Am J Geriatr Psychiatry 2013; 21:184-195)
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