Journal
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
Volume 21, Issue 12, Pages 1239-1243Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1016/j.jagp.2012.12.024
Keywords
Delirium; cerebrospinal fluid; S100B
Categories
Funding
- Research into Ageing/British Geriatrics Society Clinical Fellowship
- MRC
- BBSRC
- EPSRC
- ESRC
- MRC [MC_G0900869, G108/646] Funding Source: UKRI
- Medical Research Council [G108/646, MC_G0900869] Funding Source: researchfish
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Objectives: Delirium is associated with an increased risk of long-term cognitive decline, suggesting the possibility of concurrent central nervous system (CNS) injury. S100B is a putative biomarker of CNS injury and elevated serum levels in delirium have been reported. Here we hypothesize that delirium is associated with raised concentrations of cerebrospinal fluid(CSF) S100B. Methods: Forty-five patients with hip fracture aged over 60 and awaiting surgery under spinal anesthesia were assessed for delirium pre-and post-operatively. CSF S100B levels were measured in samples collected at the onset of surgery. Results: Participants with pre-operative delirium(N = 8) had elevated Log(10) CSF S100B (mean: -0.156; SD: 0.238) compared with those without delirium (mean: -0.306; SD: 0.162), Student's t-test t = 2.18, df = 43, p = 0.035. Conclusions: This study provides preliminary evidence of elevated CSF S100B in current delirium, consistent with findings in serumand with other studies showing elevated S100B in the presence of diverse forms of CNS injury.
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