Journal
AMERICAN JOURNAL OF GASTROENTEROLOGY
Volume 107, Issue 9, Pages 1399-1406Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ajg.2012.196
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Funding
- National Institute of Diabetes and Digestive and Kidney Diseases [K08DK064256]
- National Institutes of Health
- Crohn's and Colitis Foundation of America, Research Fellowship Award
- Broad Medical Research Program of the Broad Foundation
- National Cancer Institute [P01 CA87969, P01 CA55075, P50 CA127003]
- Merck Co.
- UCB
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OBJECTIVES: Long-term data on the influence of cigarette smoking, especially cessation, on the risk of Crohn's disease (CD) and ulcerative colitis (UC) are limited. METHODS: We conducted a prospective study of 229,111 women in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHS II). Biennially, we collected updated data on cigarette smoking, other risk factors, and diagnoses of CD or UC confirmed by medical record review. RESULTS: Over 32 years in NHS and 18 years in NHS II, we documented 336 incident cases of CD and 400 incident cases of UC. Compared with never smokers, the multivariate hazard ratio (HR) of CD was 1.90 (95 % confidence interval (CI), 1.42-2.53) among current smokers and 1.35 (95 % CI, 1.05-1.73) among former smokers. Increasing pack-years was associated with increasing risk of CD (Ptrend < 0.0001), whereas smoking cessation was associated with an attenuation of risk. By contrast, the multivariate HR of UC was 0.86 (95 % CI, 0.61-1.20) among current smokers and 1.56 (95 % CI, 1.26-1.93) among former smokers. The risk of UC was significantly increased within 2-5 years of smoking cessation (HR, 3.06; 95 % CI, 2.00-4.67) and remained persistently elevated over 20 years. CONCLUSIONS: Current smoking is associated with an increased risk of CD, but not UC. By contrast, former smoking is associated with an increased risk of UC, with risk persisting over two decades after cessation.
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