Journal
NATURE REVIEWS IMMUNOLOGY
Volume 8, Issue 12, Pages 923-934Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2449
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Funding
- National Institutes of Health [DK52539, DK64360, HL65405]
- American Diabetes Association [I03RA41]
- Ruth Kirschstein National Research Award
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The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.
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