Clinical use of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: a retrospective case series study

BackgroundFemale pattern hair loss (FPHL) is a common disorder but presents severe psychosocial problems in many female patients. Adipose tissue-derived stem cells (ADSCs) and conditioned media of ADSCs (ADSC-CM) are reported to promote hair growth in vitro. However, there are no clinical reports on the treatment of alopecia using ADSC-CM. ObjectivesThis study evaluates our clinical experience in the use of ADSC-CM for the treatment of FPHL. MethodsA retrospective, observational study of outcomes in 27 patients with FPHL treated with ADSC-CM was performed. To evaluate the efficacy of the treatment, patients' medical records and phototrichographic images were analyzed. ResultsThe application of ADSC-CM showed efficacy in treating FPHL after 12weeks of therapy. Hair density increased from 105.4 to 122.7 hairs/cm(2) (P<0.001). Hair thickness increased from 57.5m to 64.0m (P<0.001). None of the patients reported severe adverse reactions. ConclusionsThe application of ADSC-CM is a potential treatment option for FPHL.