Journal
NATURE REVIEWS IMMUNOLOGY
Volume 8, Issue 12, Pages 935-947Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2455
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Funding
- National Institutes of Health [R01CA1121100, R01AI0086899]
- leukemia research foundation
- lymphoma research foundation
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Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin(+) DC subsets that are not present in the epidermis, including a subset of DCs that is found in most non-lymphoid tissues. In this Review we describe new developments in the understanding of the biology of LCs and other langerin+ DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity.
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