4.7 Article

ATG16L1 and IL23R Are Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands

Journal

AMERICAN JOURNAL OF GASTROENTEROLOGY
Volume 103, Issue 3, Pages 621-627

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1111/j.1572-0241.2007.01660.x

Keywords

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Funding

  1. Netherlands Organization for Scientific Research [912-02-028]
  2. VICI [918.66.620]
  3. Celiac Disease Consortium
  4. Dutch government [BSIK03009]
  5. American National Institute of Diabetes and Digestive and Kidney Diseases
  6. Crohn's and Colitis Foundation of America

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BACKGROUND: Inflammatory bowel disease (IBD)-Crohn's disease (CD) and ulcerative colitis (UC)-and celiac disease are intestinal inflammatory disorders with a complex genetic background. Recently, two novel genes were found to be associated with IBD susceptibility. One, an uncommon coding variant (rs11209026) in the gene encoding for the interleukin-23 receptor (IL23R), conferred strong protection against CD. The other, rs2241880 in the autophagy-related 16-like 1 gene (ATG16L1), was associated with CD. We performed a case-control study for the association of IBD with IL23R and ATG16L1 in a Dutch cohort. We also looked at the association of IL23R and ATG16L1 with celiac disease. METHODS: Five hundred eighteen Dutch white IBD patients (311 CD and 207 UC, including 176 trios of patients with both parents), 508 celiac disease patients, and 893 healthy controls were studied for association with the rs11209026 (IL23R) and rs2241880 (ATG16L1) single nucleotide polymorphisms (SNP). RESULTS: The rs11209026 SNP in IL23R had a protective effect for IBD in the case-control analysis (odds ratio [OR] 0.19, 95% confidence interval [CI] 0.10-0.37, P = 6.6E-09). Both CD (OR 0.14, CI 0.06-0.37, P = 3.9E-07) and UC (OR 0.33, CI 0.15-0.73, P = 1.4E-03) were associated with IL23R. For ATG16L1, the rs2241880 SNP was associated with CD susceptibility (OR 1.36, CI 1.12-1.66, P = 0.0017). The population-attributable risk of carrying allele G is 0.24 and is 0.19 for homozygosity for allele G in CD. No association was found between IL23R or ATG16L1 and celiac disease. CONCLUSIONS: We confirmed the association of IL23R and ATG16L1 with CD susceptibility and also the association of IL23R with UC. We found IL23R and ATG16L1 were not associated with celiac disease susceptibility. (Am J Gastroenterol 2008;103:621-627).

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