Journal
NATURE REVIEWS CANCER
Volume 8, Issue 12, Pages 976-990Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2231
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Funding
- Ontario Institute for Cancer Research
- Canadian Cancer Society
- Canadian Institute for Health Research
- Department of Defense Breast Cancer Research Program
- Canadian Breast Cancer Research Alliance
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Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was identified. Since that time, MYC research has been intense and the advances impressive. On reflection, it is astonishing how each incremental insight into MYC regulation and function has also had an impact on numerous biological disciplines, including our understanding of molecular oncogenesis in general. Here we chronicle the major advances in our understanding of MYC biology, and peer into the future of MYC research.
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