Journal
NATURE REVIEWS IMMUNOLOGY
Volume 8, Issue 12, Pages 958-969Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2448
Keywords
-
Categories
Funding
- National Institutes of Health [AI49388, AI55576]
Ask authors/readers for more resources
Macrophages display remarkable plasticity and can change their physiology in response to environmental cues. These changes can give rise to different populations of cells with distinct functions. In this Review we suggest a new grouping of macrophage populations based on three different homeostatic activities-host defence, wound healing and immune regulation. We propose that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation. We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available