Journal
AMERICAN JOURNAL OF EPIDEMIOLOGY
Volume 179, Issue 7, Pages 824-833Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwt432
Keywords
Norwegian Mother and Child Cohort Study; perfluoroalkyl substances; perfluorooctanoic acid; perfluorooctane sulfonate; perfluoroundecanoic acid; preeclampsia
Categories
Funding
- National Institutes of Health (NIH), National Institute of Environmental Health Sciences (NIEHS)
- National Institute of Environmental Health Sciences [1-F30-ES022 126-01]
- National Institute of Child Health and Human Development [R01HD058008]
- Norwegian Ministry of Health
- Ministry of Education and Research, NIH/NIEHS [N01-ES-75558]
- NIH/National Institute of Neurological Disorders and Stroke [UO1 NS 047537-01, UO1 NS 047537-06A1]
- Norwegian Research Council/FUGE [151918/S10]
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Perfluoroalkyl substances (PFAS) are persistent and ubiquitous environmental contaminants, and human exposure to these substances may be related to preeclampsia, a common pregnancy complication. Previous studies have found serum concentrations of PFAS to be positively associated with pregnancy-induced hypertension and preeclampsia in a population with high levels of exposure to perfluorooctanoate. Whether this association exists among pregnant women with background levels of PFAS exposure is unknown. Using data from the Norwegian Mother and Child Cohort Study conducted by the Norwegian Institute of Public Health, we carried out a study of nulliparous pregnant women enrolled in 20032007 (466 cases, 510 noncases) to estimate associations between PFAS concentrations and an independently validated diagnosis of preeclampsia. We measured levels of 9 PFAS in maternal plasma extracted midpregnancy; statistical analyses were restricted to 7 PFAS that were quantifiable in more than 50 of samples. In proportional hazards models adjusted for maternal age, prepregnancy body mass index (weight (kg)/height (m)(2)), educational level, and smoking status, we observed no strongly positive associations between PFAS levels and preeclampsia. We found an inverse association between preeclampsia and the highest quartile of perfluoroundecanoic acid concentration relative to the lowest quartile (hazard ratio 0.55, 95 confidence interval: 0.38, 0.81). Overall, our findings do not support an increased risk of preeclampsia among nulliparous Norwegian women with background levels of PFAS exposure.
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