Journal
AMERICAN JOURNAL OF EPIDEMIOLOGY
Volume 176, Issue -, Pages S142-S149Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kws236
Keywords
carotid intima-media thickness; longitudinal studies; metabolism; obesity; risk factors
Categories
Funding
- National Institute of Child Health and Human Development [HD-061437, HD-062783]
- American Heart Association [0855082E]
- National Institute on Aging [AG-16592]
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Not all obese adults have cardiometabolic abnormalities. It is unknown whether this is true in children and, if true, whether children who have metabolically healthy overweight/obesity (MHO) will also have favorable cardiometabolic profiles in adulthood. These aspects were examined in 1,098 individuals who participated as both children (aged 517 years) and adults (aged 2443 years) in the Bogalusa Heart Study between 1997 and 2002 in Bogalusa, Louisiana. MHO was defined as being in the top body mass index quartile, while low density lipoprotein cholesterol, triglycerides, mean arterial pressure, and glucose were in the bottom 3 quartiles, and high density lipoprotein cholesterol was in the top 3 quartiles. Forty-six children (4.2) had MHO, and they were more likely to retain MHO status in adulthood compared with children in other categories (P 0.0001). Despite markedly increased obesity in childhood and in adulthood, these same MHO children and adults showed a cardiometabolic profile generally comparable to that of nonoverweight/obese children (P 0.05 in most cases). Moreover, there was no difference in carotid intima-media thickness in adulthood between MHO children and nonoverweight/obese children. Further, carotid intima-media thickness in adulthood was lower in MHO children than in metabolically abnormal, overweight/obese children (P 0.003). In conclusion, the MHO phenotype starts in childhood and continues into adulthood.
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