Journal
AMERICAN JOURNAL OF EPIDEMIOLOGY
Volume 175, Issue 7, Pages 653-663Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwr418
Keywords
biological markers; case-control studies; colorectal neoplasms; oxidative stress
Categories
Funding
- Directorate-General for Health and Consumers of the European Commission
- Directorate-General for Research of the European Commission
- Ligue contre le Cancer, Institut Gustave-Roussy
- Mutuelle Generale de l'Education Nationale
- Institut National de la Sante et de la Recherche Medicale (France)
- German Cancer Aid
- German Cancer Research Center
- Federal Ministry of Education and Research (Germany)
- Danish Cancer Society (Denmark)
- Spanish Ministry of Health
- Carlos III Institute, Cancer Research UK
- Medical Research Council (United Kingdom)
- Stavros Niarchos Foundation
- Hellenic Health Foundation
- Hellenic Ministry of Health and Social Solidarity (Greece)
- Italian Association for Research on Cancer
- National Research Council (Italy)
- Dutch Ministry of Public Health, Welfare and Sports
- Netherlands Cancer Registry
- LK Research Funds
- Dutch Prevention Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund
- Statistics Netherlands (the Netherlands)
- Swedish Cancer Society
- Swedish Scientific Council
- Regional Government of Vasterbotten (Sweden)
- Nordforsk-Centre of Excellence (Norway)
- Cancer Research UK [14136] Funding Source: researchfish
- Medical Research Council [G1000143, G0801056B, MC_U106179471, G0401527] Funding Source: researchfish
Ask authors/readers for more resources
Oxidative stress has been shown to play an important role in carcinogenesis, but prospective evidence for an association between biomarkers of oxidative stress and colorectal cancer (CRC) risk is limited. The authors investigated the association between prediagnostic serum levels of oxidative stress indicators (i.e., reactive oxygen metabolites (ROM) and ferric reducing ability of plasma (FRAP)) and CRC risk. This was examined in a nested case-control study (1,064 CRC cases, 1,064 matched controls) in the European Prospective Investigation Into Cancer and Nutrition cohort (1992-2003). Incidence rate ratios and 95% confidence intervals were calculated using conditional logistic regression analyses. ROM were associated with overall CRC risk (highest tertile vs. lowest: adjusted incidence rate ratio (IRRadj) = 1.91, 95% confidence interval (CI): 1.47, 2.48), proximal (IRRadj = 1.89, 95% CI: 1.06, 3.36) and distal (IRRadj = 2.31, 95% CI: 1.37, 3.89) colon cancer, and rectal cancer (IRRadj = 1.69, 95% CI: 1.05, 2.72). When results were stratified by tertile of follow-up time, the association remained significant only in participants with less than 2.63 years of follow-up (IRRadj = 2.28, 95% CI: 1.78, 2.94; P-heterogeneity < 0.01). FRAP was not associated with CRC risk. In conclusion, prediagnostic serum ROM levels were associated with increased risk of CRC. However, this association was seen only in subjects with relatively short follow-up, suggesting that the association results from production of reactive oxygen species by preclinical tumors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available