Journal
AMERICAN JOURNAL OF EPIDEMIOLOGY
Volume 174, Issue 7, Pages 816-827Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwr190
Keywords
case-control studies; diet; folic acid; Hodgkin disease; vitamins
Categories
Funding
- National Cancer Institute [P01 CA069266-01A1, T32 CA-009001-35, K07 CA115687]
- American Institute for Cancer Research
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Nutritional and genetic determinants of the one-carbon metabolism pathway have been related to risk of malignant lymphomas, but little is known about their associations with Hodgkin lymphoma risk specifically. The authors examined nutrient intake (folate, vitamin B-2, vitamin B-6, vitamin B-12, methionine) and multivitamin use among 497 Hodgkin lymphoma patients and 638 population-based controls (Massachusetts and Connecticut, 1997-2000), and genetic variation (MTHFR 677C > T, MTHFR 1298A > C, MTR 2756A > G, SHMT1 1420C > T, TYMS 1494del6) and gene-diet interactions in a subset. Unconditional logistic regression was used to calculate multivariable odds ratios and 95% confidence intervals. Hodgkin lymphoma risk was not associated with total nutrient intake or intake from food alone (excluding supplements). Multivitamin use (odds ratio (OR) = 1.46, 95% CI: 1.09, 1.96), total vitamin B-6 (ORquartile 4 vs. 1 = 1.62) (P-trend = 0.03), and total vitamin B-12 (ORquartile 4 vs. 1 = 1.75) (P-trend = 0.02) intakes were positively associated with risk of Epstein-Barr virus-negative, but not -positive, disease. The 5 genetic variants were not significantly associated with Hodgkin lymphoma risk; no significant gene-diet interactions were observed after Bonferroni correction. Study findings do not support a strong role for nutrients and genetic variation in the one-carbon metabolism pathway in susceptibility to Hodgkin lymphoma. Associations between diet and risk of Epstein-Barr virus-negative disease require confirmation in other populations.
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