Journal
AMERICAN JOURNAL OF EPIDEMIOLOGY
Volume 172, Issue 1, Pages 70-80Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwq118
Keywords
case-control studies; cohort studies; ovarian neoplasms; prospective studies; vitamin D
Categories
Funding
- National Institutes of Health, Division of Cancer Control and Population Sciences, National Cancer Institute (NCI) (Bethesda, Maryland)
- National Institutes of Health, Division of Cancer Epidemiology and Genetics, NCI
- NCI [R01 CA098661, P01 CA87969, R01 CA49449, P50 CA105009, R37 CA54281, P01 CA33619, R01 CA063464, N01-PC35137, R37 CA70867, N02-CP-11010-66, N01-CN25514]
- Georgetown University, Washington, DC [N01-CN-25522]
- Pacific Health Research Institute, Honolulu, Hawaii [N01-CN-25515]
- Henry Ford Health System, Detroit, Michigan [N01-CN-25512]
- University of Minnesota, Minneapolis, Minnesota [N01-CN-25513]
- Washington University, St. Louis, Missouri [NO1-CN-25516]
- University of Pittsburgh, Pittsburgh, Pennsylvania [N01-CN-25511]
- University of Utah, Salt Lake City, Utah [N01-CN25524]
- Marshfield Clinic Research Foundation, Marshfield, Wisconsin [N01-CN-25518]
- University of Alabama, Birmingham, Alabama [NO1-CN-75022]
- Westat, Inc., Rockville, Maryland [N01-CN-25476]
- University of California, Los Angeles, California [NO1-CN-25404]
- National Institute on Aging [U01 AG018033]
- American Cancer Society (Atlanta, Georgia)
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A role for vitamin D in ovarian cancer etiology is supported by ecologic studies of sunlight exposure, experimental mechanism studies, and some studies of dietary vitamin D intake and genetic polymorphisms in the vitamin D receptor. However, few studies have examined the association of circulating 25-hydroxyvitamin D (25(OH)D), an integrated measure of vitamin D status, with ovarian cancer risk. A nested case-control study was conducted among 7 prospective studies to evaluate the circulating 25(OH)D concentration in relation to epithelial ovarian cancer risk. Logistic regression models were used to estimate odds ratios and 95% confidence intervals among 516 cases and 770 matched controls. Compared with 25(OH)D concentrations of 50-< 75 nmol/L, no statistically significant associations were observed for < 37.5 (odds ratio (OR) = 1.21, 95% confidence interval (CI): 0.87, 1.70), 37.5-< 50 (OR = 1.03, 95% CI: 0.75, 1.41), or >= 75 (OR = 1.11, 95% CI: 0.79, 1.55) nmol/L. Analyses stratified by tumor subtype, age, body mass index, and other variables were generally null but suggested an inverse association between 25(OH)D and ovarian cancer risk among women with a body mass index of >= 25 kg/m(2) (P-interaction < 0.01). In conclusion, this large pooled analysis did not support an overall association between circulating 25(OH)D and ovarian cancer risk, except possibly among overweight women.
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