Journal
AMERICAN JOURNAL OF EPIDEMIOLOGY
Volume 173, Issue 3, Pages 282-291Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwq365
Keywords
eating; factor analysis; mental recall; neoplasms; germ cell and embryonal; prenatal nutritional physiological phenomena
Categories
Funding
- NCI NIH HHS [U10 CA98413, U10 CA98543, U10 CA098413, U10 CA098543, U54 CA163069, T32 CA099936] Funding Source: Medline
- NIMHD NIH HHS [U54 MD007593] Funding Source: Medline
Ask authors/readers for more resources
Maternal diet during pregnancy may be associated with cancer in offspring. Intake of individual foods, as well as dietary patterns, can be used when examining these relations. Here, the authors examined associations between maternal dietary intake patterns and pediatric germ cell tumors (GCTs) using principal components analysis and logistic regression. Mothers of 222 GCT cases aged less than 15 years who were diagnosed at a Children's Oncology Group institution between 1993 and 2001 and those of 336 frequency-matched controls completed a self-administered food frequency questionnaire of diet during early pregnancy. Four dietary patterns were identified: Western, fruits and vegetables, protein, and healthful. With adjustment for birth weight, parity, and vitamin use, the fruits and vegetables pattern was significantly associated with a lower odds for GCTs (odds ratio (OR) = 0.83, 95% confidence interval (CI): 0.69, 0.99; 2 sided). Upon stratification, the fruits and vegetables pattern was significantly associated with a lower odds in males (OR = 0.66, 95% CI: 0.47, 0.92) but not females (OR = 0.91, 95% CI: 0.72, 1.14). A quantitative assessment of assumed nondifferential reporting error indicated no notable deviations from unadjusted odds ratio estimates. Results of this exploratory analysis suggest that maternal prenatal dietary patterns could be considered in future studies of GCTs in offspring.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available