Journal
AMERICAN JOURNAL OF EPIDEMIOLOGY
Volume 173, Issue 2, Pages 201-216Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwq345
Keywords
African Americans; body size; breast neoplasms; Hispanic Americans; premenopause; receptors; estrogen; receptors; progesterone
Categories
Funding
- National Cancer Institute [R03 CA121875, R01 CA63446, R01 CA77305]
- US Department of Defense [DAMD17-96-1-6071]
- California Breast Cancer Research Program [4JB-1106, 7PB-0068]
- Cancer Prevention Institute of California [N01-CN-65107]
- National Cancer Institute, National Institutes of Health
- California Department of Health Service [050N-8701/8-S1522]
- Public Health Institute
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Large body size has been associated with a reduced risk of premenopausal breast cancer in non-Hispanic white women. Data on other racial/ethnic populations are limited. The authors examined the association between premenopausal breast cancer risk and adult body size in 672 cases and 808 controls aged >= 35 years from a population-based case-control study conducted in 1995-2004 in the San Francisco Bay Area (Hispanics: 375 cases, 483 controls; African Americans: 154 cases, 160 controls; non-Hispanic whites: 143 cases, 165 controls). Multivariate adjusted odds ratios and 95% confidence intervals were calculated using unconditional logistic regression. Height was associated with increased breast cancer risk (highest vs. lowest quartile: odds ratio = 1.77, 95% confidence interval: 1.23, 2.53; P-trend < 0.01); the association did not vary by hormone receptor status or race/ethnicity. Body mass index (measured as weight (kg) divided by height (m) squared) was inversely associated with risk in all 3 racial/ethnic groups, but only for estrogen receptor- and progesterone receptor-positive tumors (body mass index >= 30 vs. < 25: odds ratio = 0.42; 95% confidence interval: 0.29, 0.61). Other body size measures (current weight, body build, adult weight gain, young adult weight and body mass index, waist circumference, and waist-to-height ratio) were similarly inversely associated with risk of estrogen receptor- and progesterone receptor-positive breast cancer but not estrogen receptor- and progesterone receptor-negative disease. Despite racial/ethnic differences in body size, inverse associations were similar across the 3 racial/ethnic groups when stratified by hormone receptor status.
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