Journal
AMERICAN JOURNAL OF EPIDEMIOLOGY
Volume 169, Issue 8, Pages 1015-1024Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwp001
Keywords
creatinine; diethylhexyl phthalate; endocrine disruptors; gestational age; parturition; placenta; PPAR gamma; pregnancy
Categories
Funding
- Environmental Protection Agency [R-82943601-0]
- National Institute of Environmental Health Sciences [R01 ES013543)]
- Harvard Education and Research Center for Occupational Safety and Health [T42 OH008416]
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Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer used in consumer and medical products that can cross the placenta, disrupt steroid hormone synthesis, and activate peroxisome proliferator-activated receptor gamma. The authors examined DEHP exposure in relation to the timing of labor in a pregnancy cohort study of 283 women recruited in 4 US states (California, Iowa, Minnesota, and Missouri) between 2000 and 2004. The authors estimated associations between concentrations of DEHP metabolites and gestational age at delivery using linear regression models and associations between DEHP metabolites and clinical outcomes using logistic regression models. After covariate adjustment, women at the 75th percentile of DEHP metabolite concentrations had a 2-day-longer mean length of gestation than women at the 25th percentile (95% confidence interval: 1.4, 3.3). Log-unit increases in mono-2-ethylhexyl phthalate and mono-2-ethyl-5-oxohexyl phthalate concentrations were associated with increased odds of cesarean section delivery (30% and 50% increased odds, respectively), increased odds of delivering at 41 weeks or later (100% and 120% increased odds), and reduced odds of preterm delivery (50% and 60% decreased odds). These data suggest that DEHP may interfere with signaling related to the timing of parturition.
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