Journal
VASCULAR HEALTH AND RISK MANAGEMENT
Volume 4, Issue 6, Pages 1327-1335Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/VHRM.S4078
Keywords
endothelial; obstructive sleep apnea; inflammation; dysfunction
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Endothelial activation and inflammation are important mediators of accelerated atherogenesis and consequent increased cardiovascular morbidity in obstructive sleep apnea (OSA). Repetitive episodes of hypoxia/reoxygenation associated with transient cessation of breathing during sleep in OSA resemble ischemia/reperfusion injury and may be the main culprit underlying endothelial dysfunction in OSA. Additional factors such as repetitive arousals resulting in sleep fragmentation and deprivation and individual genetic suseptibility to vascular manifestations of OSA contribute to impaired endothelial function in OSA. The present review focuses on possible mechanisms that underlie endothelial activation and inflammation in OSA.
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