Journal
ARCHIVES OF SUICIDE RESEARCH
Volume 13, Issue 4, Pages 349-357Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/13811110903266541
Keywords
gene association; RGS2; suicidal ideation; suicide; trauma
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Funding
- NIDA NIH HHS [K24 DA015105, K24 DA15105] Funding Source: Medline
- NIMH NIH HHS [MH05220, R01 MH078928-01A1, MH078928, R01 MH078928, K08-MH070627, R21 MH074469, K08 MH070627-06, F32 MH083469-01, MH07055, K08 MH070627, R21 MH074469-02, F32 MH083469] Funding Source: Medline
- Wellcome Trust [083469] Funding Source: Medline
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This study examined whether rs4606, a single nucleotide polymorphism (SNP) in the translated region at the 3' end of RGS2, was related to suicidal ideation in an epidemiologic sample of adults living in areas affected by the 2004 Florida hurricanes. An epidemiologic sample of residents of Florida was recruited via random digit-dial procedures after the 2004 Florida hurricanes; participants were interviewed about suicidal ideation, hurricane exposure, and social support. Participants who returned buccal DNA samples via mail (n = 607) were included here. Rs4606 in RGS2 was associated with increased symptoms of current suicidal ideation (p < 0.01). Each C allele was associated with 5.59 times increased risk of having current ideation. No gene-by-environment interactions were found, perhaps due to low power. RGS2 rs4606 is related to risk of current suicidal ideation in stressor-exposed adults.
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