Journal
AMERICAN JOURNAL OF EMERGENCY MEDICINE
Volume 26, Issue 7, Pages 763-768Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ajem.2007.10.029
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- National Institutes of Health [R43-NS46822]
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Objectives: Our objective was to determine if the biomarker for axonal injury, serum cleaved tau (C-tau), predicts postconcussion syndrome (PCS) in adults after mild traumatic brain injury (mTBI). Methods: C-tau was measured from blood obtained in the emergency department. Outcome was assessed at 3 months post injury using the Rivermead Postconcussion Symptoms Questionnaire and Acute Medical Outcomes SF-36v2 Health Survey (SF-36). Results: Of 50 patients, there were 15 patients with detectable levels of C-tau, 10 patients with abnormal findings on initial head computed tomography (CT) and 22 patients with PCS. One-third of patients with detectable C-tau and 14.3% of patients without detectable C-tau had abnormal findings on head CT (P = .143). Serum C-tau was not detected more frequently in patients with PCS than those without, neither for all patients (P = .115) nor the subgroup with negative head CT (P = .253). Conclusions: C-tau is a poor predictor of PCS after mTBI regardless of head CT result. (C) 2008 Elsevier Inc. All rights reserved.
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