Journal
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volume 141, Issue 1, Pages 62-71Publisher
AMER SOC CLINICAL PATHOLOGY
DOI: 10.1309/AJCPMD5TJEFOOVBW
Keywords
Hemophagocytic; Lymphohistiocytosis; Hemophagocytosis; Bone marrow
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Funding
- National Institutes of Health research grant from the National Cancer Institute [CA-16359]
- NATIONAL CANCER INSTITUTE [P30CA016359] Funding Source: NIH RePORTER
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Objectives: To evaluate the amount of hemophagocytosis in 64 marrow core biopsy specimens and aspirates from 58 patients with clinical suspicion for secondary hemophagocytic lymphohistiocytosis (HLH) or reported findings of hemophagocytosis. Methods: A review of medical records assigned patients to a low-risk (45 patients) or high-risk (13 patients) HLH group, and association with histologic findings was examined using the Fisher exact test. Results: The amount of hemophagocytosis in aspirate or the core biopsy specimen did not correlate with disease probability (P=.17 and P=.63, respectively). Of the clinical/laboratory criteria assessed, the most significant correlations with HLH were highly elevated ferritin (P=.01), cytopenias (P=.02), and fever (P=.009). Conclusions: Our findings indicated that marrow histologic findings alone do not reliably predict the probability of HLH, and an isolated finding of hemophagocytosis, even when present in a high amount, lacks specificity for HLH.
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