Journal
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volume 141, Issue 5, Pages 630-638Publisher
OXFORD UNIV PRESS INC
DOI: 10.1309/AJCPWW2URZ9JKQJU
Keywords
Immunohistochemistry; Cytokeratin 20; SATB2; Colorectal cancer; Cancer of unknown primary (CUP)
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Funding
- Knut and Alice Wallenberg Foundation
- Uppsala University
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Objectives: Immunohistochemistry is an important extension to clinical information and morphology, and prevails as an invaluable tool for establishing a correct cancer diagnosis in clinical diagnostic pathology. The applicability of immunohistochemistry is limited by the availability of validated cell- and cancer-type specific antibodies, rendering an unmet need to discover, test, and validate novel markers. The SATB2 protein is selectively expressed in glandular cells from the lower gastrointestinal tract and expression is retained in a large majority of primary and metastatic colorectal cancers. Methods: We analyzed the expression of SATB2 in all clinical cases (n = 840), in which immunohistochemistry for detection of CK20 was deemed necessary for a final diagnosis. Results: SATB2 showed a high sensitivity (93%) and specificity (77%) to determine a cancer of colorectal origin and in combination with CK7 and CK20, the specificity increased to 100%. Conclusions: We conclude that SATB2 provides a new and advantageous supplement for clinical differential diagnostics.
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