Journal
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volume 140, Issue 5, Pages 658-669Publisher
OXFORD UNIV PRESS INC
DOI: 10.1309/AJCPDFBEBQZW1OI7
Keywords
CD177; Myelodysplasia; Flow cytometry; Neutrophil
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Objectives: To determine whether the fraction of CD177+ neutrophils might be altered in clonal myeloid disorders, similar to the skewed kappa/lambda. ratio for B-cell lymphomas, and could be used to identify myeloid neoplasms. Methods: Blood and bone marrow samples were evaluated for the fraction of CD177+ neutrophils by flow cytometry. Results: Skewed high neutrophil CD177(%) was not associated with neoplasia, but skewed low neutrophil CD177(%) was highly correlated with clonal myeloid disorders at values less than 40%. Specificity of low neutrophil CD177(%) for clonal myeloid disorders was 87% with a 40% cutoff and 95% with a 30% cutoff Findings were most pronounced for myelodysplasia, with 52% (11/21) containing fewer than 40% CD177+ neutrophils. Specificity was also suggested by normalization of neutrophil CD177(%) in four patients who reached morphologic remission after therapy for myelodysplasia or acute leukemia. Conclusions: Skewed low neutrophil CD177(%) is highly associated with clonal myeloid disorders, particularly myelodysplasia, and may be useful for detecting clonal myeloid disorders.
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