Journal
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volume 138, Issue 5, Pages 732-743Publisher
OXFORD UNIV PRESS INC
DOI: 10.1309/AJCPAGVO27RPTOTV
Keywords
Myelodysplastic syndromes; Acute myeloid leukemia; Bone marrow; CD34+cells; Flow cytometry; Antigen expression
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The World Health Organization introduced flow cytometry as an additional criterion for diagnosis of myelodysplastic syndromes (MDS). Aberrant antigen expression on bone marrow (BM) blasts may identify low-grade MDS. This study aimed to examine differences in antigen expression on CD34+ BM cells between patients with AIDS and those with secondary cytopenia. BM aspirates of 175 patients with cytopenia were classified as MDS or secondary cytopenia. Expression of stem cell antigens (CD34, CD133), myeloid antigens (CD13, CD33), B-cell antigens (CD19, CD10), growth factor receptors (CD117, CD123), and chemokine receptor (CD184) was examined. Thirty-two normal adults and 49 patients with CD34+ acute myeloid leukemia (AML) were also examined. High percentage of CD34+ cells, CD117 and CD123 overexpression, and abnormal CD45 expression on these cells are the best markers for AIDS. These phenotypic aberrancies correlate with number of blasts and degree of dysplasia, and were similar to those in CD34+ AML, thus reflecting the relationship between these disorders.
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