Journal
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volume 135, Issue 1, Pages 146-156Publisher
AMER SOC CLINICAL PATHOLOGY
DOI: 10.1309/AJCP9X8OZBEIQVVI
Keywords
Circulating tumor cells; Cytopathology; Diagnosis; Pitfalls
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Funding
- PHRC National (CHU de Nice, France)
- Conseil General 06, Nice, France
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Detection of circulating tumor cells (CTCs) morphologically may be a promising new approach in clinical oncology. We tested the reliability of a cytomorphologic approach to identify CTCs: 808 blood samples from patients with benign and malignant diseases and healthy volunteers were examined using the isolation by size of epithelial tumor cell (ISET) method. Cells having nonhematologic features (so-called circulating nonhematologic cells [CNHCs]) were classified into 3 categories: CNHCs with malignant features, CNHCs with uncertain malignant features, and CNHCs with benign features. CNHCs were found in 11.1% and 48.9% of patients with nonmalignant and malignant pathologies, respectively (P < .001). CNHCs with malignant features were observed in 5.3% and in 43.1% of patients with nonmalignant and malignant pathologies, respectively. Cytopathologic identification of CTCs using the ISET method represents a promising field for cytopathologists. The possibility of false-positive diagnosis stresses the need for using ancillary methods to improve this approach.
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